Australian Wildlife Health Network

Department of Agriculture, Fisheries and Forestry
 


Forum : Diseases and disease agents

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Topic:Devil facial tumour disease (DFTD)
Name:R Woods Date:4/10/2005 10:05:45 AM
Email:rwoods@zoo.nsw.gov.au Phone:
NameDate Of EventPostedDetails
T Grillo 10/03/2010 30/03/2010 PUBLICATION: Hannah V. Siddle, H.V. et al., (2010) MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer Proc. R. Soc. B published online before print March 10, 2010, doi:10.1098/rspb.2009.2362 http://rspb.royalsocietypublishing.org/content/early/2010/03/01/rspb.2009.2362.full?sid=d7e64e12-1069-4c37-ae88-1049d61162e2
T Grillo 10/03/2010 30/03/2010 10/03/2010 ABC Science Online http://www.abc.net.au/news/stories/2010/03/10/2841959.htm “The discovery of a genetically different population of Tasmanian devils has raised hopes for the survival of the iconic Australian mammal threatened by a deadly cancer.
T Grillo 01/03/2010 Grants to boost Devil disease research 18/02/2010 The Examiner http://www.examiner.com.au/news/local/news/environmental-issues/grants-to-boost-devil-disease-research/1755054.aspx Work on finding a vaccine for the Devil Facial Tumour Disease has received a boost with another $75,000 in grants to local and overseas research projects. The money comes directly from contributions to the Save the Tasmanian Devil Appeal. An international collaboration into understanding how DFTD cells escape the immune system has received $10,000.
T Grillo 11/02/2010 More Tasmanian Devils going into quarantine 25/01/2010 The Examiner: http://www.examiner.com.au/news/local/news/environmental-issues/more-tasmanian-devils-going-into-quarantine/1733458.aspx “UP TO 100 Tasmanian Devils from disease-free areas of western and north-western Tasmania will be quarantined over the next three months as part of the Save the Tasmanian Devil Program. Program manager Steven Smith said the disease-free animals were starting to arrive today at a specially constructed Department of Primary Industry facility at Taroona, near Hobart, as part of an insurance population.” Follow link to read full story. More news: 28/01/2010 from The Examiner: http://www.examiner.com.au/news/local/news/environmental-issues/devil-efforts-succeeding39/1735956.aspx Devil efforts `succeeding': “Efforts to save the Tasmanian devil from extinction due to the contagious facial tumour disease are succeeding, according to Trowunna Wildlife Park operator Androo Kelly. Mr Kelly, who has 38 hea
T Grillo 25/01/2010 Publication: Lachish, S. et al., (2010) Evaluation of Selective Culling of Infected Individuals to Control Tasmanian Devil Facial Tumor Disease. Conservation Biology. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/20088958?dopt =Abstract
T Grillo 19/01/2010 Publication-The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer Murchison et al., (2010) The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer. Science. 327(5961), 84 – 87. DOI: 10.1126/science.1180616. Abstract:” The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD patholog
T Grillo 19/01/2010 Publication-Transmission dynamics of Tasmanian devil facial tumor disease may lead to disease-induced extinction McCallum, H. et al., (2009) Transmission dynamics of Tasmanian devil facial tumor disease may lead to disease-induced extinction. Ecology: 90, 12, 3379-3392. doi: 10.1890/08-1763.1 Abstract: “……………………..Here we report the results of mark–recapture studies at six sites and use these data to estimate epidemiological parameters critical to both accurately assessing the risk of extinction from this disease and effectively managing this disease threat. ……………………….. Using a simple age-structured deterministic model, we show that our results are not consistent with transmission being proportional to the density of infected hosts but are consistent with frequency-dependent transmission. …………. “ http://www.esajournals.org/doi/abs/10.1890/08-1763.1
T Grillo 07/01/2010 Nature News: Hopes of a tumour test for Tasmanian devils 31/12/2009 Nature News:http://www.nature.com/news/2009/091231/full/n ews.2009.1169.html?s=news_rss “Pinpointing nerve-insulating cells as the origin of devil facial cancer could aid diagnosis and vaccination. Researchers have identified the cellular origin of the contagious cancer threatening Australia's Tasmanian devils, paving the way for a new diagnostic test and hopefully an effective vaccine.” Follow link to read more.
T Grillo 07/01/2010 • BBC: Tasmanian devil facial cancer origins 'identified' 1/01/2010 BBC News: http://news.bbc.co.uk/2/hi/science/nature/8433645.stm “Devils are susceptible to a number of different types of cancer. Just like humans, they can get breast cancer, leukaemia, etc - especially in their old age. "Sometimes it can be difficult to tell the difference between these types of cancer and the transmissible disease. "Now that we know that these very specific Schwann genes are expressed in the cancer, we can use these genes as diagnostic markers." Follow link to read more.
T Grillo 07/01/2010 Scientists discover origin of a cancer in Tasmanian devils 2/01/2010 http://www.promedmail.org/pls/otn/f?p=2400:1001:955950637964015::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,80735 -The Tasmanian devil, the spaniel-size marsupial found on the Australian island of Tasmania, has been hurtling toward extinction in recent years, the victim of a bizarre and mysterious facial cancer that spreads like a plague. Now Australian scientists say they have discovered how the cancer originated. The finding, being reported Friday [1 Jan 2010] in the journal Science, sheds light on how cancer cells can sometimes liberate themselves from the hosts where they first emerged. On a more practical level, it also opens the door to devising vaccines that could save the Tasmanian devils.” Follow link to read more. See Publications section below or follow link to read abstract on the new SCIENCE publication: http://www.sciencemag.org/cgi/content/short/327/5961/84/
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